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Azathioprine 50mg – “imuran, Azasan” “Rheumatoid Arthritis, Pain, Kidney Transplant, Transplantation, Glomerulonephritis, Hepatitis, Lupus, Myasthenia Gravis, Myopathy, Pemphigoid, Pemphigus, Nephrotic Syndrome, Inflammatory Bowel Disease, Multiple Sclerosis, Atopic Dermatitis, Restrictive Lung Disease”
Azathioprine
Azathioprine is a prescription medication used to treat rheumatoid arthritis. It is also used in kidney transplant patients to prevent rejection of the new kidney. Azathioprine belongs to a group of drugs called immunosuppressive antimetabolites, which work by decreasing the activity of the body’s immune system so it will not attack the transplanted organ or the joints.
This medication comes in tablet form and is taken once or twice a day, with or without food.
This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.
Common side effects of azathioprine include nausea, vomiting, hair loss, and rash.
Azathioprine gets broken down in the body by proteins called enzymes. Azathioprine gets converted in the body to a product (known as a metabolite) that can be toxic at high levels. An enzyme known as TMPT breaks down this metabolite so that you do not experience its harmful effects. Some patients have a change (called a mutation) in this enzyme that prevents it from breaking down the toxic metabolite properly.
Some patients have a mutation in TMPT that prevents it from breaking down toxic metabolites. These patients are more likely to experience toxic effects including the potential for lowered blood counts. A test can determine whether your TMPT enzymes carry such a mutation. Your doctor may change your dose of azathioprine based on your test results. Your doctor should also monitor your blood counts while you are being treated with azathioprine.
Steroids were withdrawn over weeks to months, azathioprine was stopped and calcineurin inhibitors were prescribed at varying doses.

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