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Seroquel is the brand name of the generic drug quetiapine, used to treat schizophrenia and bipolar disorder (formerly known as manic-depression).
Seroquel changes the levels of neurotransmitters (naturally occurring brain substances) including serotonin and dopamine.
Seroquel belongs to a class of medications called atypical antipsychotics.
The Food and Drug Administration (FDA) approved quetiapine in 1997 under the brand name Seroquel for drug manufacturer AstraZeneca.
Two years earlier, AstraZeneca agreed to pay $520 million to settle federal investigations into the drugmaker’s marketing practices for Seroquel.
Investigators had accused the company of illegally marketing the antipsychotic drug for uses that were not approved by the FDA.
Although it’s legal for a doctor to prescribe drugs for off-label purposes, it’s illegal for a drug manufacturer to actively promote any off-label use.
Off-label uses of Seroquel include treatment of aggression, Alzheimer’s disease, anxiety, attention-deficit hyperactivity disorder (ADHD), depression, post-traumatic stress disorder (PTSD), and insomnia.
Seroquel and Weight Gain Weight gain is a known side effect of taking Seroquel, and doctors have prescribed the drug off-label to treat anorexia nervosa.
However, a study published in European Eating Disorders Review in 2012 found that Seroquel did not help people with anorexia gain weight, nor did it help ease their symptoms of anxiety or depression.
Moreover, there is not enough evidence to show that the benefits of Seroquel for off-label uses outweigh the risks associated with the drug, concluded a study published in the Journal of Psychosocial Nursing and Mental Health Services in 2013.
Seroquel Warnings The FDA has placed two black-box warnings on Seroquel: First, you should not take Seroquel if you are an older person with dementia, a mental health condition that causes decreased memory, confused thinking, and changes in mood and personality.
People with dementia have an increased risk for dying while on Seroquel.
If you or a family member may have dementia, talk with a doctor about this before taking Seroquel.
Secondly, Seroquel may increase your risk for suicide.
The risk is greatest when starting treatment or increasing the dose of Seroquel, and may be higher for people younger than 24.
Let your doctor know right away if you are taking Seroquel and have: Thoughts of suicide Worsening depression Symptoms of aggression Irritability Panic attacks Extreme worry Restlessness Acting without thinking Abnormal excitement Your doctor will watch you carefully for any of these symptoms when you start Seroquel.
Also, let your friends and family members know about these symptoms.
If you have any thoughts of suicide or if a friend or family member thinks you’re acting strangely, call your doctor right away.
Experts don’t know whether Seroquel is a safe and effective treatment for schizophrenia in children younger than 13.
The safety of the drug for treating bipolar mania in children younger than 10 and bipolar depression in children younger than 18 is also unknown.
When taking Seroquel, you should avoid extreme exercise, especially in hot weather.
Drink plenty of water, especially when you are exercising or out in hot weather.
Seroquel Withdrawal Do not stop taking this drug suddenly, as it can cause withdrawal symptoms including nausea, vomiting, and sleep problems.
Seroquel may increase your risk for diabetes, so tell your doctor about any history of diabetes in you or your family.
Also, ask your doctor what symptoms of diabetes to look for while you are on Seroquel.
Other conditions to discuss with your doctor before you start Seroquel include: Irregular heartbeat History of heart attack Frequent nausea or diarrhea Cataracts Seizures High cholesterol High or low blood pressure History of stroke History of cancer Liver disease Leukopenia or neutropenia (low white blood cell count) Seroquel ‘High’ and Abuse Doctors and drug-abuse experts have noted that Seroquel has been abused by some people for a recreational “high.” According to a 2010 article in the journal Psychiatry, the drug goes by street names including “quell,” “Suzie-Q,” and “Q-ball.” Though the drug may have some appeal for its ability to cause drowsiness (somnolence), abuse of Seroquel is considered very dangerous, especially when crushed and snorted.
Pregnancy and Seroquel Seroquel is in FDA Pregnancy Category C, which means that harm to a developing fetus cannot be ruled out.
Some studies using animals have found evidence of toxic effects from taking Seroquel.
Seroquel can pass into breast milk, and the manufacturer recommends that women who are breastfeeding not use Seroquel.
In all cases, let your doctor know if you are or may become pregnant or if you are breastfeeding before taking Seroquel.
BasicDescription Back to Top Seroquel Side Effects Let your doctor know about any side effects you experience.
The most common side effects of Seroqual include: Dry mouth Sleepiness Dizziness Weight gain Constipation Indigestion Other side effects of Seroquel may include: Headache Body aches Weakness Vomiting Increased appetite and weight gain Stuffy nose Irritability Trouble concentrating, thinking, or speaking clearly Clumsiness Unusual dreams Loss of interest in sex Breast enlargement in men Missed periods in women Nipple discharge Serious side effects can occur.
If you have any of these side effects, call your doctor right away or call 9-1-1: Fainting Seizures Uncontrollable body movements Painful erection that will not go away Fever with muscle stiffness, sweating, and weakness Unusual bruising or bleeding Irregular heartbeat Fever with signs of infection Difficulty breathing or swallowing Swelling of the face, lips, or tongue Severe rash, hives, or skin blistering Any thoughts of suicide or harming yourself Back to Top Seroquel Interactions Many drugs may affect the way Seroquel works, and Seroquel may affect other drugs you are taking.
It’s very important to let your doctor know about all drugs you are taking, including illegal drugs and any over-the-counter drugs as well as herbs and supplements.
Drugs that are known to interact with Seroquel and can cause problems include: Several drugs used to treat mental illness, including antidepressants and thioridazine (Mellaril) Illegal “street drugs” Cold, cough, and allergy medications Medications used to treat fungal diseases, such as fluconazole (Diflucan), itraconazole (Sporanox) and ketoconazole (Nizoral) Medications used to treat HIV/AIDS, such as such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra) Medications used to treat heartburn Several types of antibiotics, including erythromycin (E.E.S., E-Mycin, Erythrocin) and gatifloxacin (Zymar, Zymaxid) Heart medications, including amiodarone (Cordarone), procainamide, quinidine, and sotalol (Betapace, Betapace AF, Sorine) Seizure medications, such as phenytoin ( Dilantin ) and carbamazepine ( Tegretol ) Sleeping pills Methadone Medications used to treat Parkinson’s disease, such as bromocriptine (Parlodel), cabergoline (Dostinex), and levodopa (Dopar, Larodopa) Steroids taken by mouth, including dexamethasone ( Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone) Seroquel and Alcohol Seroquel may make you feel drowsy and may affect your judgment.
Until you know how Seroquel will affect you, you should not drive or operate machinery.
Drinking alcohol may make these and other side effects of Seroquel more severe.
You should avoid alcohol while taking Seroquel.
When you are taking Seroquel, it can be harder for your body to cool down and avoid heat exhaustion.
You should avoid extreme exercise, especially in hot weather.
Make sure to drink plenty of water, especially when you are exercising or out in hot weather.
Back to Top Seroquel Dosage Typical Dosages of Seroquel A typical adult dose for schizophrenia may range from 150 to 750 milligrams (mg) a day.
A typical adult dose for bipolar disorder may range from 400 to 800 mg a day.
Your doctor will start you at a low dose and then gradually increase your dose until your symptoms improve.
You can take Seroquel with or without food.
Take the tablets whole with a glass of water.
Do not split or crush them.
Seroquel Overdose Ingesting 13.6 grams of Seroquel has resulted in a fatal overdose.
Symptoms of a Seroquel overdose may include: Vomiting Drowsiness Rapid heartbeat Dizziness Seizure Fainting If a Seroquel overdose occurs, call a poison control center at 1-800-222-1222.
If you or someone else has symptoms of an overdose, call 9-1-1.
Missed Dose of Seroquel Take Seroquel exactly as directed by your doctor.
Do not stop taking Seroquel on your own.
Stopping suddenly can cause can cause withdrawal symptoms that include nausea, vomiting, and sleep problems.
If you miss a dose of Seroquel, take the missed dose as soon as you remember.
If it is almost time for your next dose, skip the missed dose.
Do not double your dose to make up for a missed dose.
Back to Top Seroquel Pictures Seroquel 100 mg, yellow, round, film coated Seroquel 50 mg, white, round, film coated Quetiapine 25 mg-APO, pink, round, Seroquel 25 mg, peach, round, Seroquel 300 mg, white, oblong, film coated Seroquel 25 mg, peach, round, film coated Seroquel 400 mg, yellow, oblong, film coated Quetiapine 100 mg-APO, yellow, round, Quetiapine 300 mg-APO, white, capsule, Quetiapine 50 mg-APO, white, round, Quetiapine 200 mg-APO, white, round, Quetiapine 400 mg-APO, yellow, capsule, Seroquel 200 mg, white, round, film coated
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