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Progesterone is a prescription medication used to promote normal menstrual periods in women who are premenopausal but have stopped having periods due to low progesterone levels. Progesterone is also used in combination with estrogen-containing medications in postmenopausal women with a uterus to reduce the risk of developing cancer of the uterus and to prevent abnormal thickening of the lining of the uterus in women taking estrogen. Progesterone is also used to promote embryo implantation and pregnancy in conjunction with fertility treatments in women.
Progesterone belongs to a group of drugs called progestins. These work to acheive various effects in the body by mimicking the effects of naturally occuring hormones.
This medication comes in a capsule form and is typically taken once a day, at bedtime, for 10 or 12 continuous days, depending on the condition being treated.
This medication is also available in a vaginal insert form that is typically inserted into the vagina 2 to 3 times daily for up to 10 weeks of treatment.
This medication is also available in a gel form that is typically applied to the vagina once or twice a day. The frequency of application depends on the condition being treated.
This medication is also available in an injectable form to be given directly into a muscle by a healthcare provider, typically daily, for 6 to 8 days.
The choice of progesterone therefore involves not only its effect on the endometrium in synergy with estrogen, but also possible residual androgenic activity which may have negative metabolic repercussions.
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