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Duloxetine is a prescription medicine used to treat major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Duloxetine is in a group of medications called SNRIs (serotonin norepinephrine reuptake inhibitors). It works by increasing the amount of serotonin and norepinephrine in the brain to promote mental balance and stop the movement of pain signals to the brain.
This medication comes in capsule form and is taken once or twice daily, with or without food.
Common side effects include nausea, dry mouth, and sleepiness. Do not drive or operate heavy machinery until you know how duloxetine affects you.
Duloxetine is a prescription medicine used to treat major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Duloxetine may be found in some form under the following brand names:
Duloxetine is part of the drug class:
​Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:  
The most common side effects of duloxetine are:
This is not a complete list of duloxetine side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you are taking or are planning to take including prescription and non-prescription medicines, vitamins and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of duloxetine drug interactions. Ask your doctor or pharmacist for more information.
Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:
More important information about antidepressants:
Duloxetine can cause sleepiness. Do not drive or operate heavy machinery until you know how duloxetine affects you.
These are not all the possible side effects. Call your doctor for medical advice about side effects. 
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of duloxetine there are no specific foods that you must exclude from your diet when receiving duloxetine.
Before taking duloxetine, tell your doctor about all of your medical conditions. Especially tell your doctor if you have:
Tell your doctor about all of the medicines you take, or are planning to take, including prescription and non-prescription medicines, vitamins and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
This medication falls into category C. There are no well-controlled studies that have been done in pregnant women. Duloxetine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed. Duloxetine may be excreted in human breast milk. It is not known how duloxetine will affect your baby.
Duloxetine comes as a delayed-release (long-acting) capsule to take by mouth. It is usually taken once a day with or without food. Swallow the capsules whole; do not crush or chew them. Take duloxetine at around the same time(s) every day. Take duloxetine exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.
Duloxetine may help control your symptoms but will not cure your condition. It may take 1 to 4 weeks or longer before you feel the full benefit of duloxetine. Continue to take duloxetine even if you feel well. Do not stop taking duloxetine without talking to your doctor. Your doctor will probably decrease your dose gradually.
Take duloxetine exactly as your doctor prescribes it. Follow the directions on your prescription label. Your doctor may start you on a low dose of medication and increase your dose after one week. Your doctor will determine the best dose for you.
When duloxetine is used to treat depression, it is usually taken once or twice a day. When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day.
If you take too much of this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.
WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of duloxetine or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Duloxetine is not approved for use in pediatric patients.

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