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  • In one embodiment, the ibuprofen and the famotidine are in separate compartments in the oral dosage form. In one embodiment the oral dosage form comprises a first portion containing ibuprofen and a second portion containing famotidine, where the famotidine is in the form of barrier-coated particles distributed in the ibuprofen portion. In one embodiment the oral unit dosage form contains about 800 mg ibuprofen and about 26.67 mg famotidine or about 400 mg ibuprofen and about 13.33 mg famotidine. The method involves administering to patients in the population an oral unit dosage form containing ibuprofen and famotidine, where the ibuprofen and famotidine are in a weight ratio in the range of 29:1 to 31:1, and the oral unit dose form is administered three-times-per-day. The method involves administering an oral dosage form containing a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine, where the oral dosage form is administered three times per day (TID).
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