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Indomethacin (Indocin) is a prescription drug used to treat moderate to severe pain, swelling, and stiffness from arthritis.
Indomethacin belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
These drugs treat swelling, pain, and fever by blocking the production of substances in the body called prostaglandins, which regulate inflammation and other bodily processes.
Indomethacin is approved to treat: Moderate to severe osteoarthritis (wear-and-tear arthritis) Rheumatoid arthritis (inflammatory arthritis) Ankylosing spondylitis (inflammatory arthritis of the spine) Doctors may also use indomethacin to treat bursitis (shoulder joint inflammation), gout, or gouty arthritis, (a form of arthritis caused by crystals of uric acid building up inside joints), and inflammation of tendons (tissue that attaches muscles to bones).
The Food and Drug administration (FDA) approved indomethacin in 1965 for the drug company Iceutica Operations under the brand name Indocin.
Today, several drug manufacturers make generic versions of the drug.
It’s also sold under other brand names, including Indo-Lemmon and Tivorbex.
NLRP3 mRNA expression increased after indomethacin administration, whereas that of other NLRs such as NLRP6 and NLRC4 did not.
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