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Additional information about the drug Isoptin

Calan, Covera HS, Isoptin SR, Verelan are the brand names of the drug verapamil, which is used to treat high blood pressure and control chest pain known as angina.
The immediate-release tablet form of this medication is also used to prevent and treat irregular heartbeats ( arrhythmia ).
Although this medicine is not approved by the FDA for migraines, it is often prescribed for preventing them.
Isoptin is in a class of drugs called calcium channel blockers.
It works by relaxing blood vessels so the heart doesn’t have to work as hard, increasing the supply of blood and oxygen to the heart, and slowing electrical activity in the heart to control heart rate.
Isoptin was approved by the Food and Drug Administration (FDA) in 1981.
The drug comes as a tablet, an extended-release tablet, and an extended-release capsule to take by mouth and injectable solution.
Isoptin is on the World Health Organization’s “List of Essential Medicines,” a list of the most important drugs needed in a basic health care system.
Isoptin Warnings This medicine controls high blood pressure, arrhythmia, and angina, but it does not cure these conditions.
You should continue to take verapamil even if you feel well.
Before taking verapamil, tell your doctor if you have or have ever had: Any condition that causes food to move through your digestive system more slowly Myasthenia gravis (a condition that causes certain muscles to weaken) Heart failure Heart, liver, or kidney disease Muscular dystrophy (an inherited disease that causes weakening of the muscles).
You should also tell your doctor you are taking verapamil before any type of surgery, including dental procedures.
Your doctor will likely start you on a low dose of verapamil and then gradually increase your dose.
You should keep all appointments with your doctor while taking this medicine.
You will need your blood pressure checked regularly to determine how you are responding to verapamil.
If you take a certain version of the extended-release tablets, you might notice an empty tablet shell in your stool.
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  • Drug classes used preventively include beta-blockers, tricyclic antidepressants, anti-convulsants (e.g., divalproex sodium, topiramate), calcium channel blockers (e.g., verapamil), cyproheptadine, and NSAIDs (e.g. naproxen). Unlike drugs that ablate cluster headache (abortive drugs), most of the drugs used to prevent cluster headache have been developed for other clinical conditions and unfortunately, their effectiveness in prevention is limited. Tricyclic anti-depressants including amitriptyline HCl, doxepin HCl and nortriptyline HCl are commonly used.
  • Freedman, B., Dunn, R.F., Richmond, D. et al (1981). Coronary artery spasm during exercise treatment with verapamil.
  • It may be necessary to decrease the dosage of verapamil when it is administered to patients receiving non-depolarizing or polarizing neuromuscular blockers.
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