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Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation. : 334
Its name derives from its systematic name, di me thyl phen yl am inobenzo ic acid. It was discovered and brought to market by Parke-Davis in the 1960s. It became generic in the 1980s and is available worldwide under many brand names.
Contents
1 Medical use
2 Side effects
3 Mechanism of action
4 History
5 Society and culture
5.1 Availability and pricing
5.2 Synthesis
6 Research
7 See also
8 References
9 Sources
Medical use
Mefenamic acid is used to treat moderate pain and menstrual pain.
There is evidence that supports the use of mefenamic acid for perimenstrual migraine headache prophylaxis, with treatment starting 2 days prior to the onset of flow or 1 day prior to the expected onset of the headache and continuing for the duration of menstruation.
Side effects
Mefenamic acid is recommended to be taken with food.
Known mild side effects of mefenamic acid include headaches, nervousness, and vomiting. Serious side effects may include diarrhea, hematemesis (vomiting blood), hematuria (blood in urine), blurred vision, skin rash, itching and swelling, sore throat and fever.
In 2008 the US label was updated with a warning concerning a risk of premature closure of the ductus arteriosus in pregnancy.
Mechanism of action
Like other members of the anthranilic acid derivatives (or fenamate) class of NSAID drugs, it inhibits both isoforms of COX and prevents formation of prostaglandins.
History
Scientists led by Claude Winder from Parke-Davis invented mefenamic acid in 1961, along with fellow members of the class of anthranilic acid derivatives, flufenamic acid in 1963 and meclofenamate sodium in 1964. : 918–919
It was approved in the UK in 1963 as “Ponstan”, in West Germany in 1964 as “Ponalar”, and in France as “Ponstyl” and the US in 1967 as “Ponstel”. : 918–919
Society and culture
Availability and pricing
Mefenamic acid is generic and is available worldwide under many brand names.
In the US, wholesale price of a week’s supply of generic mefenamic acid has been quoted as $426.90 in 2014. Brand-name Ponstel is $571.70. In the Philippines, 10 tablets of 500 mg generic mefenamic acid cost PHP39.00 (or the equivalent of US$0.88) as of October 25, 2014.
Synthesis
Analogous to fenamic acid, this compound may be made from 2-chlorobenzoic acid and 2,3-dimethylaniline.
Research
While studies have been conducted to see if mefenamic acid can improve behavior in transgenic mouse models of Alzheimer’s disease
See also
Niflumic acid

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