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Norgestrel, sold under the brand name Ovral among others, is a progestin medication which is used in birth control pills and in menopausal hormone therapy.
Side effects of norgestrel include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others.
Norgestrel was introduced for medical use, specifically in birth control pills, in 1966.
Contents
1 Medical uses
2 Side effects
3 Pharmacology
3.1 Pharmacodynamics
3.2 Pharmacokinetics
4 Chemistry
4.1 Synthesis
5 History
6 Society and culture
6.1 Generic names
6.2 Brand names
7 See also
8 References
Medical uses
Norgestrel is used in combination with ethinylestradiol or quinestrol in combined birth control pills, alone in progestogen-only birth control pills, and in combination with estradiol or conjugated estrogens in menopausal hormone therapy.
Side effects
See also: Levonorgestrel § Side effects, and Progestin § Side effects
Pharmacology
Pharmacodynamics
See also: Levonorgestrel § Pharmacodynamics
Norgestrel is a progestogen, or an agonist of the progesterone receptor.
Relative affinities (%) of levonorgestrel and metabolites
Compound
PR
AR
ER
GR
MR
SHBG
CBG
Levonorgestrel
150–162
34 a, 45
0
1–8
17–75
50
0
5α-Dihydrolevonorgestrel
50
38 a
0
?
?
?
?
3α,5α-Tetrahydrolevonorgestrel
?
?
0.4
?
?
?
?
3β,5α-Tetrahydrolevonorgestrel
?
?
2.4
?
?
?
?
Values are percentages (%). Reference ligands (100%) were promegestone for the PR, metribolone ( a = mibolerone ) for the AR, E2 for the ER, DEXA for the GR, aldosterone for the MR, DHT for SHBG, and cortisol for CBG. Sources:
Pharmacokinetics
See also: Levonorgestrel § Pharmacokinetics
The pharmacokinetics of norgestrel have been reviewed.
Chemistry
See also: List of progestogens, List of androgens/anabolic steroids, and Levonorgestrel
Norgestrel, also known as rac -13-ethyl-17α-ethynyl-19-nortestosterone or as rac -13-ethyl-17α-ethynylestr-4-en-17β-ol-3-one, is a synthetic estrane steroid and a derivative of testosterone.
Synthesis
Chemical syntheses of norgestrel have been published.
History
Norgestrel was first introduced, as a birth control pill in combination with ethinylestradiol, under the brand name Eugynon in Germany in 1966.
Society and culture
Generic names
Norgestrel is the generic name of the drug and its INN, USAN, USP, BAN, DCF, DCIT, and JAN.
Brand names
Norgestrel has been marketed under a variety of brand names including Cyclacur, Cryselle, Cyclo-Progynova, Duoluton, Elinest, Eugynon, Microgynon, Lo/Ovral, Low-Ogestrel, Logynon, Microlut, Minicon, Nordette, Neogest, Ogestrel, Ovral, Ovran, Ovranette, Ovrette, Planovar, Prempak, Progyluton, and Trinordiol among others.
See also
Elsimar M. Coutinho
Herchel Smith

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