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Etodolac is a nonsteroidal anti-inflammatory drug ( NSAID ) approved by the U.S. Food and Drug Administration in January 1991.
As of 2015 the cost for a typical month of medication in the United States is less than 25 USD.
1 Medical uses
2 Indications
3 Interactions
4 Pregnancy and nursing
5 Brand names
6 References
7 External links
Medical uses
See also: NSAIDs
NSAIDs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the cyclooxygenase (abbrev. COX) enzymes which form prostanoids, resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
Post-marketing studies demonstrated that etodolac inhibition of cyclooxygenase is somewhat COX-2 selective
Etodolac is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis.
Etodolac should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can worsen both conditions. Etodolac is used with caution in patients taking blood thinning medications ( anticoagulants ), such as warfarin (Coumadin), because it increases the risk of bleeding. Patients taking both lithium and etodolac may develop toxic blood lithium levels. Additionally, etodolac has been found to interact with certain anti-depressant medications, such as sertraline or fluoxetine, which can increase risks of stroke, heart attack, and other cardiovascular conditions. Patients also taking ciclosporin (Sandimmune) can develop kidney toxicity. Use in children has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of surgery. Etodolac metabolites may also cause a false positive bilirubin result on a urinalysis test.
Box, strip and tablet of etodolac (Lodine SR) 600mg
Pregnancy and nursing
Etodolac is generally avoided during pregnancy and nursing. NSAIDs may cause adverse cardiovascular effects in the fetus during pregnancy.
Brand names
Etodolac is manufactured by Almirall Limited under the trade name Lodine SR
The drug is also sold under several other brand names, including:
“Etogesic” ( India )
Etova ( India )
Dualgan ( Portugal )
Etodin ( South Korea )
Etofree ( India )
Etopan ( Israel )
Flancox ® ( Brazil )
Haipen ( Japan )
Lodine ( France, Switzerland, United States )
Proxym (S Etodolac) ( India )
Etol ( Turkey )
Lonine ( Taiwan )
Etodine ( Egypt )
Dolarit (Turkey)
“Etodin Fort” ( Bulgaria )

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